New Hope for Alzheimer’s Treatment

By Sondra Forsyth

A relatively frequent genetic variant turns out to provide significant protection against Alzheimer’s disease and can delay the onset of the disease by as much as four years. That is the finding of research done by Judes Poirier, PhD, C.Q., and colleagues at the Douglas Mental Health Institute and McGill University in Montréal. The discovery opens new avenues for treatment against this devastating disease. Dr. presented the study at the annual Alzheimer’s Association International Conference in Copenhagen in July 2014.

A release from the university quotes Dr. Poirier as saying, “We found that specific genetic variants in a gene called HMG CoA reductase which normally regulates cholesterol production and mobilization in the brain can interfere with, and delay the onset of Alzheimer’s disease by nearly four years. This is an exciting breakthrough in a field where successes have been scarce these past few years. Dr. Poirier’s previous research led to the discovery that a genetic variant was formally associated with the common form of Alzheimer’s disease.

“These latest genetic results from Dr. Poirier’s team are an important step forward in the understanding of Alzheimer’s disease neurobiology, and also the use of genetics to identify an interesting new molecular target that is amenable to therapeutic development” added Brigitte Kieffer, Scientific Director of the Research Centre of the Douglas Mental Health University Institute.”

Over the past two decades, research efforts around the globe have focused on identifying genetic and environmental factors responsible for causing or accelerating the progression of the common form of Alzheimer’s disease. However, little was known about possible protective genetic factors that can delay or even prevent the disease onset in humans. It is well documented that a subset of older individuals who happen to be carriers of predisposing genetic factors for the common form of Alzheimer’s manage to escape the disease and live long and productive lives without any memory problems until their 90’s.