Antibiotics for Simple Staph Infections?

By Jane Farrell

Although the overuse of antibiotics has raised concerns about whether to give the medicines to children with simple staph infections, new research indicates that doing so may reduce the risk of such infections later on.

That conclusion was reached by investigators led by Washington University School of Medicine in St. Louis. It was published online in the journal Clinical Infectious Diseases. The study was conducted with researchers from Southern Illinois University School of Medicine.

“There have been conflicting data about the benefit to antibiotics in minor staph infections,” said the study’s senior author, Stephanie A. Fritz, MD, a Washington University associate professor of pediatrics in the Division of Infectious Diseases. “It is definitely important to surgically remove pus from the infection site, but also giving antibiotics means that the child will be less likely to see a doctor again in several months for another staph infection.”

According to a news release from Washington University, the researchers evaluated 383 children — with a median age of 3 years old — whose infections with the bacteria Staphylococcus aureus (staph) required incision and drainage. (Simple staph infections look like pus-filled bug bites; see illustration above for microscopic view.) The patients also had colonization of staph in their nostrils or on their skin.

The children were evaluated for the bacteria and reinfection several times over a year; of these patients, 355 (93 percent) received antibiotics coupled with incision and drainage treatment.

A month after initial infection, bacterial swab tests found that half of the children (178) who had received antibiotics had no signs of staph living on their skin or in their nostrils, reducing the risk of recurring infection. However, the bacteria remained on the skin of about three-fourths of the children (26) who did not receive antibiotics.

Additionally, children who remained colonized with staph a month after initial infection were about twice as likely to experience a recurrent infection than those who did not have staph on their skin. That’s 101 children (60 percent) compared with 54 children (30 percent).

Staph generally live harmlessly on the skin in about one-third of the human population, Fritz said. However, staph infections have become a worsening health problem, affecting not only those with weakened immune systems but otherwise healthy children and adults.

At St. Louis Children’s Hospital, where Fritz treats patients, about 50 children are hospitalized each year with staph infections. Overall, about 800 children admitted to the hospital’s emergency department each year have staph infections; most are treated and discharged.

“In recent years, studies have demonstrated that staph infections are prominent in both hospitals and in the community,” Fritz said. “For example, we have seen a dramatic increase in community-associated infections since 2000.”

Staph may become life-threatening when it enters the bloodstream, bones or organs through skin-to-skin contact or by touching a contaminated object. When an infection turns serious, health-care workers typically give patients intravenous antibiotics. 

However, some health-care workers have hesitated prescribing antibiotics for children with minor staph infections because of increasing antibiotic resistance. The most common such strain is known as methicillin-resistant Staphylococcus aureus, or MRSA, which may cause pneumonia, severe organ damage and death. The Centers for Disease Control and Prevention reports that 11,000 adults and children die annually of MRSA infections.

Although it might seem counterintuitive, prescribing antibiotics for minor staph infections helps to reduce antibiotic resistance, said the study’s first author, Patrick Hogan, a clinical research specialist at the School of Medicine. “Using antibiotics judiciously to treat staph infections eliminates staph colonization and prevents more infection from occurring in the future,” he said. “This reduces the overall burden of the staph germ on the environment and people, which results in less recurrence and, therefore, less antibiotic use.”

The study primarily evaluated the antibiotics clindamycin and trimethoprim-sulfamethoxazole (TMP-SMX). Of the two drugs, clindamycin was the most effective at eliminating staph colonization and preventing recurrent infection. It’s not yet known why clindamycin was superior to other antibiotics, Hogan said.