Are You Really Allergic to Aspirin?

By Sondra Forsyth

Some patients with cardiovascular disease who have a reaction to aspirin are told they are allergic without being tested by an allergist. As a result they stop an otherwise effective therapy. According to a study presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in San Antonio in November 2015, 34 percent of patients studied were mistakenly labeled as having aspirin hypersensitivity if they had a history of any gastrointestinal symptoms. The study authors reviewed 5,052 medical records and found aspirin hypersensitivity in only 2.5 percent (131) of the patients. Hypersensitivity is an exaggerated immune response by the body to an agent, but is not the same as a diagnosed allergy.

A release from ACAA quotes lead author Gabriela Orgeron, MD as saying, “Our study showed none of the patients that were determined to have aspirin hypersensitivity were referred to an allergist for testing to determine if they had a true allergy. In addition, we found that patients with GI symptoms were mislabeled as having aspirin allergy, which likely deprived them of being treated with aspirin in the future.”

While one patient in the study had a severe allergic reaction (anaphylaxis) and one patient had respiratory symptoms, skin reactions were the most commonly documented reaction, found in 19 percent of the patients. In 39 percent of the cases there was not proper documentation of the type of reaction that occurred.

“It’s very important that, similar to penicillin, anyone thought to have an aspirin allergy be referred to an allergist for testing,” said allergist and study author Sudhir Sekhsaria, MD, ACAAI fellow. “In cases such as those shown in the study, patients are frequently told to discontinue aspirin therapy or are switched to another medication when there is no reason to do so. Allergists can help identify true allergies, and if they are present, help patients find the right course of therapy. If there is not a true allergy, they can help explore how to manage symptoms.”