Breakthrough in Understanding Parkinson's Disease

By Jane Farrell

Scientists at Trinity College Dublin have made an important breakthrough in the understanding of Parkin, a protein that regulates the repair and replacement of nerve cells within the brain. The discovery generates a new perspective on how nerve cells die in Parkinson’s disease. The Trinity research group, led by Seamus Martin,Smurfit Professor of Medical Genetics, published its findings in November 2014 in Cell Reports.

A release from the college explains that although mutation of Parkin has been known to lead to an early onset form of Parkinson’s for many years, understanding what it actually does within cells has been difficult. Now Professor Martin and colleagues have discovered that in response to specific types of cell damage, Parkin can trigger the self-destruction of “injured” nerve cells by switching on a controlled process of “cellular suicide” called apoptosis.

Using cutting-edge research techniques, the Martin laboratory, funded by Science Foundation Ireland, found that damage to mitochondria (which function as “cellular battery packs”) activates the Parkin protein, which results in one of two different outcomes – either self-destruction or a repair mode. Which outcome is chosen depends on the degree of damage suffered by the cellular battery packs.

These new findings suggest that one of the problems in Parkinson’s disease may be the failure to clear away sick nerve cells with faulty cellular battery packs in order to make way for healthy replacements. Instead, sickly and dysfunctional nerve cells may accumulate, which effectively prevents the recruitment of fresh replacements.

The release quotes Professor Martin as sayingm “This discovery is surprising and turns on its head the way we thought that Parkin functions. Until now, we have thought of Parkin as a brake on cell death within nerve cells, helping to delay their death. However, our new data suggests the contrary: Parkin may in fact help to weed out injured and sick nerve cells, which probably facilitates their replacement. This suggests that Parkinson’s disease could result from the accumulation of defective neurons due to the failure of this cellular weeding process. We are very grateful for the support of Science Foundation Ireland, who funded this research. This work represents an excellent example of how basic research leads to fundamental breakthroughs in our understanding of how diseases arise. Without such knowledge, it would be very difficult to develop new therapies.”